Cannabis sativa active compounds are extensively studied for their therapeutic effects, beyond the properly-identified psychotropic activity. C. Sativais employed to treat different healthcare indications, such as a number of sclerosis, spasticity, epilepsy, ulcerative colitis and discomfort. Simultaneously, standard analysis is discovering new constituents of cannabis-derived compounds and their receptors capable of neuroprotection and neuronal activity modulation. The function of the several phytochemicals in diverse therapeutic processes is not completely understood, but their important function is beginning to emerge and be appreciated. In this evaluation, we will contemplate the structure-activity connection (SAR) of cannabinoid compounds capable to bind to cannabinoid receptors and act as therapeutic agents in neuronal ailments, e.g., Parkinson’s illness.
Copyright © 2018 Elsevier B.V. All rights reserved.
PMID: 29941830 PMCID: PMC6099582 DOI: 10.3390/molecules23071526
Prandi C1, Blangetti Mtwo, Namdar Dthree, Koltai Hfour.